{"id":16797,"date":"2019-04-09T08:46:44","date_gmt":"2019-04-09T06:46:44","guid":{"rendered":"https:\/\/fundaciongaem.org\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/"},"modified":"2019-04-09T08:36:36","modified_gmt":"2019-04-09T06:36:36","slug":"nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica","status":"publish","type":"post","link":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/","title":{"rendered":"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica"},"content":{"rendered":"<ul>\n<li class=\"sidebar-right\">\n<h3>Es tracta d&#8217;una t\u00e8cnica pionera a nivell mundial per tractar l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica, dues malalties neurodegeneratives que avui en dia encara no tenen curaci\u00f3<\/h3>\n<\/li>\n<li id=\"main\" class=\"sidebar-right\">\n<h3>La investigaci\u00f3, una iniciativa de Fundaci\u00f3 GAEM, subvencionada per l&#8217;Obra Social &#8220;la Caixa&#8221; i desenvolupada a l&#8217;Hospital Cl\u00ednic &#8211; IDIBAPS, demostra la seguretat de la ter\u00e0pia cel\u00b7lular<\/h3>\n<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Investigadors de l&#8217;<a href=\"https:\/\/www.hospitalclinic.org\/ca\" target=\"_blank\" rel=\"noopener noreferrer\">Hospital Cl\u00ednic<\/a> &#8211; <a href=\"http:\/\/www.idibaps.org\/index.html\" target=\"_blank\" rel=\"noopener noreferrer\">IDIBAPS<\/a>, amb la col\u00b7laboraci\u00f3 de quatre centres espanyols m\u00e9s, han publicat un estudi a la revista <a href=\"https:\/\/www.pnas.org\/content\/early\/2019\/04\/02\/1820039116\" target=\"_blank\" rel=\"noopener noreferrer\"><em>Proceedings of the National Academy of Sciences<\/em> (PNAS)<\/a> en el que demostren que la <strong>ter\u00e0pia cel\u00b7lular basada en c\u00e8l\u00b7lules dendr\u00edtiques tolerog\u00e8niques<\/strong> \u00e9s segura i no presenta efectes adversos en el tractament de pacients amb esclerosi m\u00faltiple (EM) i neuromielitis \u00f2ptica (NMO). Aquest tipus de c\u00e8l\u00b7lules, que s&#8217;obtenen de la sang del propi pacient, estan modificades per inhibir la resposta inflamat\u00f2ria caracter\u00edstica d&#8217;aquestes malalties.<\/p>\n<p>L&#8217;assaig, <strong>impulsat per la Fundaci\u00f3 Grup d&#8217;Afectats d&#8217;Esclerosi M\u00faltiple (GAEM) i &#8220;la Caixa&#8221;<\/strong>, ha estat coordinat per <strong>Pablo Villoslada<\/strong>, cap del grup IDIBAPS Esclerosi M\u00faltiple Patog\u00e8nesi i Noves Ter\u00e0pies i de la Universitat de Barcelona, i <strong>Daniel Ben\u00edtez<\/strong>, facultatiu de la Secci\u00f3 de Immunoter\u00e0pia del Servei d&#8217;Immunologia de l&#8217;Hospital Cl\u00ednic &#8211; IDIBAPS.<\/p>\n<p>\u00c9s el primer assaig cl\u00ednic que ha incl\u00f2s pacients de NMO, considerada per la seva incid\u00e8ncia (5-10 persones de cada 100.000), com una malaltia rara.<\/p>\n<p>Els resultats de l&#8217;assaig cl\u00ednic han demostrat tamb\u00e9 que aquesta ter\u00e0pia cel\u00b7lular \u00e9s capa\u00e7 d&#8217;activar una part del sistema immune que \u00e9s responsable d&#8217;acabar amb la inflamaci\u00f3, i d&#8217;aquesta manera seria possible aturar el dany que aquestes malalties causen al cervell. At\u00e8s que aquest primer estudi ha obtingut resultats positius a nivell de seguretat i efic\u00e0cia, es planteja prosseguir els assajos amb un nou estudi en fase 2 que determini l&#8217;efic\u00e0cia cl\u00ednica en el control de l&#8217;EM per evitar l&#8217;augment de la discapacitat.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Dues malalties inflamat\u00f2ries que afecten el sistema nervi\u00f3s<\/strong><\/p>\n<p>L&#8217;<a href=\"https:\/\/fundaciongaem.org\/ca\/que-es-la-esclerosis-multiple\/\" target=\"_blank\" rel=\"noopener noreferrer\">esclerosi m\u00faltiple<\/a> \u00e9s una malaltia del sistema nervi\u00f3s cr\u00f2nica i inflamat\u00f2ria que destrueix la subst\u00e0ncia protectora de les fibres nervioses, la mielina. Es tracta de la segona causa de discapacitat neurol\u00f2gica en adults joves (20-40 anys), i afecta m\u00e9s a les dones que als homes.<\/p>\n<p>La inflamaci\u00f3 que es produeix durant els brots de la malaltia provoca episodis transitoris de p\u00e8rdua de for\u00e7a, sensibilitat o visi\u00f3, per\u00f2 amb el temps l&#8217;EM es converteix en una malaltia degenerativa, amb un augment progressiu de les seq\u00fceles. Els s\u00edmptomes varien d&#8217;una persona a una altra, i l&#8217;evoluci\u00f3 ve determinada per l&#8217;\u00e0rea danyada.<\/p>\n<blockquote><p>\u00abEn l&#8217;actualitat, no existeixen ter\u00e0pies per curar de forma definitiva aquesta malaltia, i els tractaments existents, que tenen nombrosos efectes secundaris, nom\u00e9s s\u00f3n efica\u00e7os parcialment, i m\u00e9s en les fases inicials\u00bb, assenyala <strong>Pablo Villoslada<\/strong>, coordinador de l&#8217;estudi.<\/p><\/blockquote>\n<p>La <a href=\"https:\/\/fundaciongaem.org\/esclerosis-multiple-en-linea\/neuromielitis-optica\/\" target=\"_blank\" rel=\"noopener noreferrer\">neuromielitis \u00f2ptica<\/a>, per la seva banda, \u00e9s una malaltia rara del sistema nervi\u00f3s, tamb\u00e9 d&#8217;origen inflamatori. Es caracteritza per brots que poden causar ceguesa o provocar paraplegia. T\u00e9 una incid\u00e8ncia menor que l&#8217;esclerosi m\u00faltiple, per\u00f2 \u00e9s m\u00e9s greu perqu\u00e8 produeix majors seq\u00fceles.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>La ter\u00e0pia cel\u00b7lular en el tractament de l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica<\/strong><\/p>\n<p>La ter\u00e0pia amb c\u00e8l\u00b7lules dendr\u00edtiques tolerog\u00e8niques \u00e9s un tipus de ter\u00e0pia cel\u00b7lular amb l&#8217;objectiu de modular les defenses del pacient de forma espec\u00edfica i selectiva per frenar la inflamaci\u00f3 que causen l&#8217;EM i la NMO sense alterar la resta de les defenses.<\/p>\n<p>&nbsp;<\/p>\n<p><img fetchpriority=\"high\" decoding=\"async\" data-src=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/Terapia-celular_Tolernacia-inmune_IDIBAPS-e1554801144495.png\" class=\"aligncenter wp-image-13330 size-full lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"\" width=\"530\" height=\"373\" \/><noscript><img decoding=\"async\" class=\"aligncenter wp-image-13330 size-full\" src=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/Terapia-celular_Tolernacia-inmune_IDIBAPS-e1554801144495.png\" alt=\"\" width=\"530\" height=\"373\"><\/noscript><\/p>\n<p>&nbsp;<\/p>\n<p>El tractament consisteix a a\u00efllar i madurar al laboratori un tipus de gl\u00f2buls blancs de la sang, les c\u00e8l\u00b7lules dendr\u00edtiques, i fer-les tolerants a prote\u00efnes de la mielina i del cervell contra les que reacciona el sistema immune dels pacients. La maduraci\u00f3 d&#8217;aquestes c\u00e8l\u00b7lules al laboratori est\u00e0 dirigida al fet que suprimeixin la inflamaci\u00f3 en comptes de promoure-la. Donat que les c\u00e8l\u00b7lules s\u00f3n del propi pacient (aut\u00f2logues), no pateixen rebuig i poden realitzar la seva funci\u00f3 despr\u00e9s de ser injectades.<\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" data-src=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/Terapia-celular_Tolernacia-inmune_IDIBAPS_2-e1554801197905.jpg\" class=\"aligncenter wp-image-13329 size-full lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" alt=\"\" width=\"535\" height=\"401\" \/><noscript><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-13329 size-full\" src=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/Terapia-celular_Tolernacia-inmune_IDIBAPS_2-e1554801197905.jpg\" alt=\"\" width=\"535\" height=\"401\"><\/noscript><\/p>\n<p>En l&#8217;assaig que publica la revista PNAS, i que es va posar en marxa a finals de 2015, hi van participar 12 pacients, 8 amb EM i 4 amb NMO. L&#8217;objectiu de l&#8217;estudi va ser verificar la seguretat del tractament i l&#8217;abs\u00e8ncia d&#8217;efectes adversos moderats o greus.<\/p>\n<blockquote><p>\u00abEls resultats d&#8217;aquest estudi de fase 1 demostren que el tractament \u00e9s segur en les dosis provades, i hem comprovat el seu efecte en el sistema immune, el que permet continuar amb els assajos cl\u00ednics\u00bb, explica Pablo Villoslada.<\/p><\/blockquote>\n<p>En el mateix estudi s&#8217;ha dut a terme una an\u00e0lisi de marcadors immunol\u00f2gics associats a les dues malalties esmentades.<\/p>\n<blockquote><p>\u00abGr\u00e0cies a aquesta an\u00e0lisi, hem pogut observar que les c\u00e8l\u00b7lules dendr\u00edtiques produ\u00efdes al laboratori tenen un perfil &#8220;tolerog\u00e8nic&#8221; o antiinflamatori, \u00e9s a dir, que estan orientades a inhibir la resposta inflamat\u00f2ria, que \u00e9s l&#8217;objectiu de la ter\u00e0pia. En concret, hem observat que el tractament indueix la producci\u00f3 de gl\u00f2buls blancs reguladors (anomenats Tr1), que podrien restaurar la toler\u00e0ncia immune natural. Encara falta per determinar si els canvis observats en la resposta immunit\u00e0ria dels pacients tractats produeix una millora de l&#8217;evoluci\u00f3 cl\u00ednica\u00bb, explica Daniel Ben\u00edtez.<\/p><\/blockquote>\n<p>&nbsp;<\/p>\n<p><strong>Propers passos<\/strong><\/p>\n<p>El seg\u00fcent pas \u00e9s dur a terme un assaig de fase 2 amb m\u00e9s pacients que demostri que aquesta estrat\u00e8gia terap\u00e8utica \u00e9s cl\u00ednicament efica\u00e7.<\/p>\n<p>Els investigadors assenyalen que l&#8217;aplicaci\u00f3 d&#8217;aquest tipus de ter\u00e0pia no nom\u00e9s suposa un gran pas endavant per a aquestes dues malalties neurol\u00f2giques, sin\u00f3 que s&#8217;espera que pugui aplicar-se en altres malalties autoimmunes i reumatol\u00f2giques, com les encefalitis autoimmunes, l&#8217;artritis reumatoide o la psoriasi.<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p>&nbsp;<\/p>\n<p><strong>Article cient\u00edfic publicat a la revista PNAS: <\/strong><\/p>\n<p><a href=\"https:\/\/www.pnas.org\/content\/early\/2019\/04\/02\/1820039116\" target=\"_blank\" rel=\"noopener noreferrer\"><strong>Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial<\/strong><\/a><\/p>\n<p>&nbsp;<\/p>\n<p><strong>Not\u00edcies a premsa:<\/strong><\/p>\n<p><a href=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/20190413_abc-salud.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Esclerosis M\u00faltiple: Restaurar las defensas<\/a>\u00a0|\u00a0ABC<\/p>\n<p><a href=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/Un-ensayo-demuestra-que-una-terapia-celular-restaura-el-sistema-inmune-en-esclerosis-m\u00faltiple_LaVanguardia.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Un ensayo demuestra que una terapia celular restaura el sistema inmune en esclerosis m\u00faltiple<\/a>\u00a0| LA VANGUARDIA<\/p>\n<p><a href=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/20190409-PNAS-Razon.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Nueva terapia celular para reparar el sistema inmune en la Esclerosis M\u00faltiple<\/a>\u00a0| LA RAZ\u00d3N<\/p>\n<p><a href=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/20190415_El-Espa%C3%B1ol.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">La investigaci\u00f3n crea m\u00e9todos menos agresivos contra la esclerosis m\u00faltiple<\/a> | EL ESPA\u00d1OL<\/p>\n<p><a href=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/20190408_La-Voz-de-Galicia.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">Una terapia celular restaura el sistema inmune en pacientes con esclerosis<\/a>\u00a0| LA VOZ DE GALICIA<\/p>\n<p><a href=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2019\/04\/20190408_Noticia-IDIBAPS_Diario-Medico.png\" target=\"_blank\" rel=\"noopener noreferrer\">Nueva terapia celular para esclerosis m\u00faltiple y neuromielitis \u00f3ptica<\/a> | DIARIO M\u00c9DICO<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Investigadors de l&#8217;Hospital Cl\u00ednic &#8211; IDIBAPS, amb la col\u00b7laboraci\u00f3 de quatre centres espanyols m\u00e9s, han publicat a la revista Proceedings of the National Academy of Sciences (PNAS) un estudi impulsat per Fundaci\u00f3 GAEM i &#8220;la Caixa&#8221;, en el qual demostren que la ter\u00e0pia cel\u00b7lular basada en c\u00e8l\u00b7lules dendr\u00edtiques tolerog\u00e8niques \u00e9s segura i no presenta efectes adversos en el tractament de pacients amb esclerosi m\u00faltiple (EM) i neuromielitis \u00f2ptica (NMO).<\/p>\n","protected":false},"author":1,"featured_media":16540,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[210],"tags":[2039,1795,1541,1542,1796,1797,1743,2040,1613,1583,2014],"class_list":["post-16797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-fundacio-gaem","tag-cellules-dendritiques","tag-celulas-dendriticas","tag-esclerosi-multiple","tag-esclerosis-multiple","tag-hospital-clinic","tag-idibaps","tag-neuromielitis-optica","tag-sistema-immune","tag-terapia-cellular","tag-terapia-celular","tag-tolerancia-immune","category-210","description-off"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#039;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#039;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\" \/>\n<meta property=\"og:description\" content=\"Investigadors de l&#039;Hospital Cl\u00ednic - IDIBAPS, amb la col\u00b7laboraci\u00f3 de quatre centres espanyols m\u00e9s, han publicat a la revista Proceedings of the National Academy of Sciences (PNAS) un estudi impulsat per Fundaci\u00f3 GAEM i &quot;la Caixa&quot;, en el qual demostren que la ter\u00e0pia cel\u00b7lular basada en c\u00e8l\u00b7lules dendr\u00edtiques tolerog\u00e8niques \u00e9s segura i no presenta efectes adversos en el tractament de pacients amb esclerosi m\u00faltiple (EM) i neuromielitis \u00f2ptica (NMO).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/\" \/>\n<meta property=\"og:site_name\" content=\"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/FundacioGaem\/\" \/>\n<meta property=\"article:published_time\" content=\"2019-04-09T06:46:44+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2024\/03\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"992\" \/>\n\t<meta property=\"og:image:height\" content=\"661\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"PROGRAMADOR\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@fundaciongaem\" \/>\n<meta name=\"twitter:site\" content=\"@fundaciongaem\" \/>\n<meta name=\"twitter:label1\" content=\"Escrit per\" \/>\n\t<meta name=\"twitter:data1\" content=\"PROGRAMADOR\" \/>\n\t<meta name=\"twitter:label2\" content=\"Temps estimat de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minuts\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/\"},\"author\":{\"name\":\"PROGRAMADOR\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#\\\/schema\\\/person\\\/093d963705cb588ce96ffe4a15bde10c\"},\"headline\":\"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica\",\"datePublished\":\"2019-04-09T06:46:44+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/\"},\"wordCount\":1168,\"publisher\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fundaciongaem.org\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg\",\"keywords\":[\"C\u00e8l\u00b7lules dendr\u00edtiques\",\"C\u00e9lulas dendr\u00edticas\",\"Esclerosi M\u00faltiple\",\"Esclerosis M\u00faltiple\",\"Hospital Cl\u00ednic\",\"IDIBAPS\",\"neuromielitis \u00f3ptica\",\"sistema immune\",\"ter\u00e0pia cel\u00b7lular\",\"Terapia Celular\",\"toler\u00e0ncia immune\"],\"articleSection\":[\"GAEM\"],\"inLanguage\":\"ca\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/\",\"url\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/\",\"name\":\"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l'esclerosi m\u00faltiple i la neuromielitis \u00f2ptica - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/fundaciongaem.org\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg\",\"datePublished\":\"2019-04-09T06:46:44+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#breadcrumb\"},\"inLanguage\":\"ca\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#primaryimage\",\"url\":\"https:\\\/\\\/fundaciongaem.org\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg\",\"contentUrl\":\"https:\\\/\\\/fundaciongaem.org\\\/wp-content\\\/uploads\\\/2024\\\/03\\\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg\",\"width\":992,\"height\":661},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Portada\",\"item\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/inicio\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#website\",\"url\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/\",\"name\":\"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"ca\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#organization\",\"name\":\"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\",\"url\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/fundaciongaem.org\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/LOGO-2.png\",\"contentUrl\":\"https:\\\/\\\/fundaciongaem.org\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/LOGO-2.png\",\"width\":354,\"height\":132,\"caption\":\"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\"},\"image\":{\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/FundacioGaem\\\/\",\"https:\\\/\\\/x.com\\\/fundaciongaem\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/2454646\",\"https:\\\/\\\/www.instagram.com\\\/fundaciongaem\\\/cebook.com\\\/FundacioGaem\\\/\",\"https:\\\/\\\/www.youtube.com\\\/user\\\/fundaciogaem\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/#\\\/schema\\\/person\\\/093d963705cb588ce96ffe4a15bde10c\",\"name\":\"PROGRAMADOR\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"ca\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b57ee1544b5750bf1116758aec83af4d7c9709bbc2131c9e1568d92ff8d2e28b?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b57ee1544b5750bf1116758aec83af4d7c9709bbc2131c9e1568d92ff8d2e28b?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/b57ee1544b5750bf1116758aec83af4d7c9709bbc2131c9e1568d92ff8d2e28b?s=96&d=mm&r=g\",\"caption\":\"PROGRAMADOR\"},\"sameAs\":[\"https:\\\/\\\/fundaciongaem.org\"],\"url\":\"https:\\\/\\\/fundaciongaem.org\\\/ca\\\/author\\\/gaem\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l'esclerosi m\u00faltiple i la neuromielitis \u00f2ptica - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/","og_locale":"ca_ES","og_type":"article","og_title":"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l'esclerosi m\u00faltiple i la neuromielitis \u00f2ptica - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)","og_description":"Investigadors de l'Hospital Cl\u00ednic - IDIBAPS, amb la col\u00b7laboraci\u00f3 de quatre centres espanyols m\u00e9s, han publicat a la revista Proceedings of the National Academy of Sciences (PNAS) un estudi impulsat per Fundaci\u00f3 GAEM i \"la Caixa\", en el qual demostren que la ter\u00e0pia cel\u00b7lular basada en c\u00e8l\u00b7lules dendr\u00edtiques tolerog\u00e8niques \u00e9s segura i no presenta efectes adversos en el tractament de pacients amb esclerosi m\u00faltiple (EM) i neuromielitis \u00f2ptica (NMO).","og_url":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/","og_site_name":"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)","article_publisher":"https:\/\/www.facebook.com\/FundacioGaem\/","article_published_time":"2019-04-09T06:46:44+00:00","og_image":[{"width":992,"height":661,"url":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2024\/03\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg","type":"image\/jpeg"}],"author":"PROGRAMADOR","twitter_card":"summary_large_image","twitter_creator":"@fundaciongaem","twitter_site":"@fundaciongaem","twitter_misc":{"Escrit per":"PROGRAMADOR","Temps estimat de lectura":"6 minuts"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#article","isPartOf":{"@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/"},"author":{"name":"PROGRAMADOR","@id":"https:\/\/fundaciongaem.org\/ca\/#\/schema\/person\/093d963705cb588ce96ffe4a15bde10c"},"headline":"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica","datePublished":"2019-04-09T06:46:44+00:00","mainEntityOfPage":{"@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/"},"wordCount":1168,"publisher":{"@id":"https:\/\/fundaciongaem.org\/ca\/#organization"},"image":{"@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#primaryimage"},"thumbnailUrl":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2024\/03\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg","keywords":["C\u00e8l\u00b7lules dendr\u00edtiques","C\u00e9lulas dendr\u00edticas","Esclerosi M\u00faltiple","Esclerosis M\u00faltiple","Hospital Cl\u00ednic","IDIBAPS","neuromielitis \u00f3ptica","sistema immune","ter\u00e0pia cel\u00b7lular","Terapia Celular","toler\u00e0ncia immune"],"articleSection":["GAEM"],"inLanguage":"ca"},{"@type":"WebPage","@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/","url":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/","name":"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l'esclerosi m\u00faltiple i la neuromielitis \u00f2ptica - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)","isPartOf":{"@id":"https:\/\/fundaciongaem.org\/ca\/#website"},"primaryImageOfPage":{"@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#primaryimage"},"image":{"@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#primaryimage"},"thumbnailUrl":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2024\/03\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg","datePublished":"2019-04-09T06:46:44+00:00","breadcrumb":{"@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#breadcrumb"},"inLanguage":"ca","potentialAction":[{"@type":"ReadAction","target":["https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/"]}]},{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#primaryimage","url":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2024\/03\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg","contentUrl":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2024\/03\/Terapia-celular_Tolernacia-inmune_IDIBAPS_3.jpg","width":992,"height":661},{"@type":"BreadcrumbList","@id":"https:\/\/fundaciongaem.org\/ca\/nova-terapia-cellular-per-restaurar-el-sistema-immune-en-lesclerosi-multiple-i-la-neuromielitis-optica\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Portada","item":"https:\/\/fundaciongaem.org\/ca\/inicio\/"},{"@type":"ListItem","position":2,"name":"Nova ter\u00e0pia cel\u00b7lular per restaurar el sistema immune en l&#8217;esclerosi m\u00faltiple i la neuromielitis \u00f2ptica"}]},{"@type":"WebSite","@id":"https:\/\/fundaciongaem.org\/ca\/#website","url":"https:\/\/fundaciongaem.org\/ca\/","name":"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)","description":"","publisher":{"@id":"https:\/\/fundaciongaem.org\/ca\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/fundaciongaem.org\/ca\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"ca"},{"@type":"Organization","@id":"https:\/\/fundaciongaem.org\/ca\/#organization","name":"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)","url":"https:\/\/fundaciongaem.org\/ca\/","logo":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/fundaciongaem.org\/ca\/#\/schema\/logo\/image\/","url":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2023\/11\/LOGO-2.png","contentUrl":"https:\/\/fundaciongaem.org\/wp-content\/uploads\/2023\/11\/LOGO-2.png","width":354,"height":132,"caption":"GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)"},"image":{"@id":"https:\/\/fundaciongaem.org\/ca\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/FundacioGaem\/","https:\/\/x.com\/fundaciongaem","https:\/\/www.linkedin.com\/company\/2454646","https:\/\/www.instagram.com\/fundaciongaem\/cebook.com\/FundacioGaem\/","https:\/\/www.youtube.com\/user\/fundaciogaem"]},{"@type":"Person","@id":"https:\/\/fundaciongaem.org\/ca\/#\/schema\/person\/093d963705cb588ce96ffe4a15bde10c","name":"PROGRAMADOR","image":{"@type":"ImageObject","inLanguage":"ca","@id":"https:\/\/secure.gravatar.com\/avatar\/b57ee1544b5750bf1116758aec83af4d7c9709bbc2131c9e1568d92ff8d2e28b?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/b57ee1544b5750bf1116758aec83af4d7c9709bbc2131c9e1568d92ff8d2e28b?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/b57ee1544b5750bf1116758aec83af4d7c9709bbc2131c9e1568d92ff8d2e28b?s=96&d=mm&r=g","caption":"PROGRAMADOR"},"sameAs":["https:\/\/fundaciongaem.org"],"url":"https:\/\/fundaciongaem.org\/ca\/author\/gaem\/"}]}},"publishpress_future_workflow_manual_trigger":{"enabledWorkflows":[]},"_links":{"self":[{"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/posts\/16797","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/comments?post=16797"}],"version-history":[{"count":0,"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/posts\/16797\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/media\/16540"}],"wp:attachment":[{"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/media?parent=16797"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/categories?post=16797"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/fundaciongaem.org\/ca\/wp-json\/wp\/v2\/tags?post=16797"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}