{"id":18627,"date":"2021-01-26T14:06:30","date_gmt":"2021-01-26T13:06:30","guid":{"rendered":"https:\/\/fundaciongaem.org\/tindrem-una-vacuna-contra-lesclerosi-multiple-el-2021\/"},"modified":"2021-01-26T14:06:30","modified_gmt":"2021-01-26T13:06:30","slug":"tindrem-una-vacuna-contra-lesclerosi-multiple-el-2021","status":"publish","type":"post","link":"https:\/\/fundaciongaem.org\/ca\/tindrem-una-vacuna-contra-lesclerosi-multiple-el-2021\/","title":{"rendered":"Tindrem una vacuna contra l’esclerosi m\u00faltiple el 2021?"},"content":{"rendered":"

El desenvolupament de vacunes contra la COVID-19 ha impulsat l’estudi de vacunes contra l’esclerosi m\u00faltiple, amb esperan\u00e7adores perspectives<\/h3>\n

En un article de The Conversation<\/a>, Fernando de Castro<\/a>, Cient\u00edfic Titular de l’CSIC i cap de grup de recerca. Neuroci\u00e8ncies, Instituto Cajal – CSIC<\/a>,, reflexiona sobre l’abast de les proves realitzades recentment amb vacunes anti Covid-19 i les troballes que estableixen una relaci\u00f3 amb un possible tractament per a l‘esclerosi m\u00faltiple<\/a>. Reumimos aqui pel seu inter\u00e8s l’article de Fernando de Castro.<\/p>\n

El mateix grup que va sintetitzar la vacuna de Pfizer\/BioNTech<\/a> contra la Covid-19<\/a>\u00a0ha assajat amb \u00e8xit una altra vacuna d’ARN missatger (ARNm) que suprimeix els s\u00edmptomes en diversos models animals d’esclerosi m\u00faltiple. Sorgeixen diversos punts que mereixen un comentari per a p\u00fablic en general:<\/p>\n

    \n
  1. \n
      \n
    1. El tractament amb la “vacuna” d’ARNm ( “m1\u03a8 mRNA” \u00e9s el seu nom exacte) suprimeix, selectivament, la resposta immune dels limf\u00f2cits T reguladors<\/a> contra la mielina, per\u00f2 no contra la resta.<\/li>\n
    2. El tractament amb la “vacuna” suprimeix completament el desenvolupament de s\u00edmptomes en el model animal de l’esclerosi m\u00faltiple quan s’aplica abans que apareguin els s\u00edmptomes (el que podria considerar-se com a tractament preventiu).<\/li>\n
    3. Quan s’aplica una vegada que els animals tenen s\u00edmptomes, aquests reverteixen considerablement. Els animals recuperen part o fins i tot tota la seva motilitat (el que els propis autors atribueixen a un efecte antiinflamatori, no reparador).<\/li>\n
    4. Els investigadors tamb\u00e9 van provar el tractament en ratolins que desenvolupen el model d’esclerosi m\u00faltiple de forma recurrent i m\u00e9s semblant a la forma cl\u00ednica m\u00e9s freq\u00fcent que s’observa en els pacients (esclerosi m\u00faltiple recurrent-remitent). Els s\u00edmptomes tamb\u00e9 desapareixen, no del tot per\u00f2 s\u00ed significativament, un cop ja s’han iniciat o fins i tot durant el seu primer pic.<\/li>\n
    5. El tractament suprimeix els limf\u00f2cits T autoreactius espec\u00edfics d’ant\u00edgens de mielina<\/a> (els que ataquen la mielina en la malaltia). A m\u00e9s, a l’promoure els limf\u00f2cits T reguladors aconsegueix que el balan\u00e7 immunol\u00f2gic es desplaci cap a les formes supressores.<\/li>\n<\/ol>\n<\/li>\n<\/ol>\n

       <\/p>\n

      Fundaci\u00f3 GAEM impulsa la innovaci\u00f3 biom\u00e8dica per trobar una cura per l’esclerosi m\u00faltiple i millorar la vida de m\u00e9s de 55.000 persones a Espanya. D\u00f3na suport la seva tasca d’investigaci\u00f3<\/a> i sensibilitzaci\u00f3 sobre aquesta malaltia que no t\u00e9 cura.<\/p>\n

      Amb aquesta nova i prometedora aproximaci\u00f3 terap\u00e8utica es podria tractar de forma nova malalties autoimmunes com l’esclerosi m\u00faltiple. La producci\u00f3 d’ARNm adequadament modificat i la seva inclusi\u00f3 en nanopart\u00edcules<\/a> liposomals \u00e9s una cosa factible, r\u00e0pida, relativament barata i, a m\u00e9s, permetria abordar el tractament personalitzat dels pacients. Per exemple, es podrien generar ARNm modificats espec\u00edficament contra cada autoant\u00edgen<\/a> identificat en aquest pacient.<\/p>\n

      Tal com s’ha parlat per al tractament de la Covid-19, aquest tipus de vacunes suposen una revoluci\u00f3 en el tractament de moltes malalties. Segons els resultats en el model animal, tamb\u00e9 en aquesta plaga que \u00e9s l’esclerosi m\u00faltiple.<\/p>\n

      Per\u00f2 no hem d’oblidar que es tracta d’un assaig precl\u00ednic i que encara queda molt cam\u00ed per rec\u00f3rrer<\/strong> abans de poder pensar en veure aquest tipus de tractament en cl\u00ednica. Fa falta molta investigaci\u00f3 b\u00e0sica i assajos cl\u00ednics seq\u00fcencials en pacients.<\/p>\n

       <\/p>\n

      Llegir l’article complet<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

      El desenvolupament de vacunes contra la COVID-19 ha impulsat l’estudi de vacunes contra l’esclerosi m\u00faltiple, amb esperan\u00e7adores perspectives.
      \nEn un article de The Conversation, Fernando de Castro, Cient\u00edfic Titular de l’CSIC i cap de grup de recerca. Neuroci\u00e8ncies, Instituto Cajal – CSIC,, reflexiona sobre l’abast de les proves realitzades recentment amb vacunes anti Covid-19 i les troballes que estableixen una relaci\u00f3 amb un possible tractament per a l’esclerosi m\u00faltiple. Reumimos aqui pel seu inter\u00e8s l’article de Fernando de Castro.<\/p>\n","protected":false},"author":1,"featured_media":18039,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[212],"tags":[1588,1826,1541,1619,3616],"class_list":["post-18627","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-em-i-nmo","tag-esclerosimultiple","tag-covid-19","tag-esclerosi-multiple","tag-investigacio-en-esclerosi-multiple","tag-vacunes","category-212","description-off"],"acf":[],"yoast_head":"\nTindrem una vacuna contra l'esclerosi m\u00faltiple el 2021? - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fundaciongaem.org\/ca\/tindrem-una-vacuna-contra-lesclerosi-multiple-el-2021\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Tindrem una vacuna contra l'esclerosi m\u00faltiple el 2021? - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)\" \/>\n<meta property=\"og:description\" content=\"El desenvolupament de vacunes contra la COVID-19 ha impulsat l'estudi de vacunes contra l'esclerosi m\u00faltiple, amb esperan\u00e7adores perspectives. 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