{"id":18657,"date":"2021-09-22T08:37:33","date_gmt":"2021-09-22T06:37:33","guid":{"rendered":"https:\/\/fundaciongaem.org\/lesclerosi-multiple-familiar-es-mes-comuna-en-nens-dones-i-climes-mes-calids\/"},"modified":"2021-09-22T08:37:33","modified_gmt":"2021-09-22T06:37:33","slug":"lesclerosi-multiple-familiar-es-mes-comuna-en-nens-dones-i-climes-mes-calids","status":"publish","type":"post","link":"https:\/\/fundaciongaem.org\/ca\/lesclerosi-multiple-familiar-es-mes-comuna-en-nens-dones-i-climes-mes-calids\/","title":{"rendered":"L’esclerosi m\u00faltiple familiar \u00e9s m\u00e9s comuna en nens, dones i climes m\u00e9s c\u00e0lids"},"content":{"rendered":"

L’esclerosi m\u00faltiple heredit\u00e0ria o familiar passa amb m\u00e9s freq\u00fc\u00e8ncia en nens, dones i persones que viuen en climes m\u00e9s c\u00e0lids<\/h3>\n

 <\/p>\n

\u00c9s el que suggereix l’estudi, “La prevalen\u00e7a global de l’esclerosi m\u00faltiple familiar: una revisi\u00f3 sistem\u00e0tica actualitzada i una metan\u00e0lisi<\/a>“, publicat a la revista\u00a0BMC<\/span>\u00a0Neurology<\/span><\/a>.<\/p>\n

L’esclerosi m\u00faltiple<\/a> (EM) \u00e9s la causa m\u00e9s comuna de discapacitat neurol\u00f2gica no traum\u00e0tica i afecta m\u00e9s de 2,5 milions de persones a tot el m\u00f3n. Se’n desconeix la causa exacta de\u00a0l’EM<\/span>, per\u00f2 es creu que \u00e9s provocada per factors ambientals i gen\u00e8tics.<\/p>\n

Els factors ambientals relacionats amb l’EM inclouen<\/span>\u00a0la infecci\u00f3 pel virus d’Epstein<\/span>–Barr<\/span><\/a>, la defici\u00e8ncia de vitamina D, la manca de llum solar, el tabaquisme, l’obesitat i la latitud (dist\u00e0ncia des de l’equador).<\/p>\n

Encara que molts gens estan implicats en\u00a0l’EM<\/span>, els canvis en el gen HLA-DRB1*15:01 estan associats amb el risc m\u00e9s gran de desenvolupar\u00a0EM<\/span>. Les persones que hereten la mutaci\u00f3 d’un dels pares tenen un risc 3,5 vegades m\u00e9s gran de desenvolupar\u00a0EM<\/span>, que es multiplica per vuit si s’hereta dels dos pares.<\/p>\n

Estudis anteriors han intentat determinar la freq\u00fc\u00e8ncia de l’her\u00e8ncia de\u00a0l’EM<\/span> dins de les fam\u00edlies (EM familiar). Tot i aix\u00f2, aquests estudis s’han centrat nom\u00e9s en les taxes d’her\u00e8ncia en familiars de primer grau i han ignorat els de segon i tercer grau.<\/p>\n

A l’estudi actual, els investigadors de l’Iran van intentar ampliar el coneixement actual de la prevalen\u00e7a de\u00a0l’EM<\/span> familiar mitjan\u00e7ant la investigaci\u00f3 de les taxes globals en nens i adults, i tant en homes com en dones. Tamb\u00e9 van examinar les taxes d’EM familiar segons l’\u00e0rea geogr\u00e0fica i la latitud.<\/p>\n

L’equip va buscar articles de recerca de revisi\u00f3 per parells que investiguessin les taxes d’EM familiar que es van publicar entre el 1984 i el 2020. Despr\u00e9s d’excloure els articles que no complien els seus criteris, es van incloure un total de 49 estudis de 46 articles amb una mostra de 16.179 casos d’EM familiar a l’an\u00e0lisi final.<\/p>\n

La taxa de prevalen\u00e7a total d’EM familiar al grup analitzat va ser de l’11,8%, amb la prevalen\u00e7a m\u00e9s alta trobada a Saskatchewan, Canad\u00e0 (32,7%) i la m\u00e9s baixa a Hongria (2,2%).<\/p>\n

 <\/p>\n

La Fundaci\u00f3 GAEM<\/a> impulsa la innovaci\u00f3 biom\u00e8dica per trobar una cura per a l’esclerosi m\u00faltiple<\/strong> i millorar la vida de m\u00e9s de 55.000 persones a Espanya. Recolza la seva tasca de recerca<\/a> i sensibilitzaci\u00f3 sobre aquesta malaltia que no t\u00e9 cura.<\/p>\n

 <\/p>\n

L’EM familiar es va presentar m\u00e9s sovint en nens (15,5%) que en adults (10,8%), i la seva aparici\u00f3 en adults va ser a una edat mitjana de 28,7 anys, cosa que indica una edat d’aparici\u00f3 m\u00e9s primerenca en comparaci\u00f3 amb els casos espor\u00e0dics (no hereditaris) d’EM.<\/p>\n

L’EM familiar tamb\u00e9 va afectar les dones amb m\u00e9s freq\u00fc\u00e8ncia que els homes: 15,4% davant del 13,7%, respectivament.<\/p>\n

Curiosament, l’an\u00e0lisi de subgrups va revelar que l’EM familiar es presenta amb una freq\u00fc\u00e8ncia significativament menor a latituds m\u00e9s altes ia regions amb alta prevalen\u00e7a d’EM<\/strong>.<\/p>\n

Els investigadors van suggerir que una consci\u00e8ncia p\u00fablica m\u00e9s gran sobre l’EM en regions amb altes taxes de malaltia i l’assessorament gen\u00e8tic poden haver redu\u00eft els matrimonis entre les fam\u00edlies afectades, cosa que porta a taxes m\u00e9s baixes d’EM familiar en aquestes regions.<\/p>\n

En general, “les troballes d’aquest estudi van demostrar que la prevalen\u00e7a de FMS [EM familiar] \u00e9s m\u00e9s gran en els casos d’EM d’inici pedi\u00e0tric que en els casos d’EM d’inici en adults, \u00e9s diferent entre \u00e0rees geogr\u00e0fiques i es redueix amb la m\u00e9s prevalen\u00e7a i latitud de l’EM<\/em>“. van concloure els investigadors. “A m\u00e9s, els s\u00edmptomes s’inicien relativament a edats m\u00e9s primerenques en els casos de FMS<\/em>“.<\/p>\n

Tot i aix\u00f2, l’equip ha assenyalat que es necessiten estudis a llarg termini per confirmar les troballes i donar temps per al desenvolupament de nous casos en familiars.<\/p>\n

 <\/p>\n

Llegir l’article sencer a MSNews Today<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

L’esclerosi m\u00faltiple heredit\u00e0ria o familiar passa amb m\u00e9s freq\u00fc\u00e8ncia en nens, dones i persones que viuen en climes m\u00e9s c\u00e0lids, segons suggereix un estudi publicat a la revista BMC Neurology.<\/p>\n","protected":false},"author":1,"featured_media":18084,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[212],"tags":[3609,1695,3619,3624],"class_list":["post-18657","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-em-i-nmo","tag-escleriosimultiple","tag-em","tag-escleriosi-multiple","tag-escleriosi-multiple-familar","category-212","description-off"],"acf":[],"yoast_head":"\nL'esclerosi m\u00faltiple familiar \u00e9s m\u00e9s comuna en nens, dones i climes m\u00e9s c\u00e0lids - GAEM (Grupo de Afectados de Esclerosis M\u00faltiple)<\/title>\n<meta name=\"robots\" content=\"index, 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