The most innovative therapeutic strategies in Multiple Sclerosis are based on neuroprotection and remyelination, both processes that are considered a cure and not a modification of the disease.
Besides current treatments —based on corticosteroids to treat outbreaks and immunosuppressants to control the immune response and inflammation— and its new developments, biomedical science is investigating mechanisms of action that affect the targets of the disease:
- Neurons should be protected in order to prevent a cellular attack to the immune system, which would stop the disease.
- Myelin, from which regeneration or remyelination is sought, which would help the affected person to recover those functional areas affected by the disease. This would represent a cure and would reverse the effects of multiple sclerosis.
Both the protection of neurons and the regeneration of myelin are approaches of the so-called personalized medicine, a new concept that aims to find the specific and appropriate therapy for each patient according to their particular clinical history.
Personalized medicine is based on the genetic and environmental information of each individual and it tailors the prevention, diagnosis and treatment of the disease for each patient.
To do this, early diagnosis techniques are used, with molecular and image markers specific to multiple sclerosis, and new therapeutic strategies aimed at molecular mechanisms, such as gene and cell therapy, and vaccines.
Infografy about personalized medicine (Roche)
The action mechanisms of new therapeutic strategies can be classified into three large families:
- Cell therapy
- Gene Therapy
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